Scientific Programme

Pre-Event:  Symposium in honour of Professors Julijana Kristl and Stanko Srčič on their retirement

The symposium will be held in person at Faculty of Pharmacy University of Ljubljana for invited colleagues who so-created the professional carrier of professors Julijana Kristl and Stanko Srčič. The official language will be Slovenian.

Participants of the BBBB conference are kindly invited to participate this event virtually, starting at 15.00 (link).

Conference registration

Conference opening

[PL] Development and translation of lead compounds for the treatment of neurodegenerative diseases.
Stanislav Gobec, University of Ljubljana, Faculty of Pharmacy, Slovenia

Section: NEW TRENDS IN INDUSTRIAL PHARMACY

Section: NEW MOLECULES FOR TREATING NEVRODEGENERATIVE DISEASES

[KL] Scientific and regulatory approaches in formulation development with poorly soluble drugs
Hatice Yeşim Karasulu, Ege University, Turkey

[KL] Synthesis and transformations of kynurenic acid derivatives with potential neuroprotective activity
István Szatmári, University of Szeged, Hungary

[KL] The power of data science in pharmaceutical industry
Biljana Janković, Lek, Sandoz & University of Ljubljana, Slovenia

[KL] Simple syntheses of synthons for potential anti-Alzheimer and antiviral drugs
Urban Košak, University of Ljubljana, Slovenia

Coffee break & Poster session

Continuous manufacturing in solid dose – how to leverage opportunities of this new technology (Promotion lecture)
Leo Ohrem, Merck

[OP] Influence of the binder jetting process parameters and binder liquid composition on the relevant attributes of 3D printed tablets
Klemen Kreft, University of Ljubljana, Slovenia

[OP] Optimization of radial extrusion and pellet coating processes using PAT approaches
Aljoša Gradišek, Krka, Slovenia

[OP] From batch technology to continouos manufacturing: formulation of gastroretentive dosage form based on melt foaming technique
Gábor Vasvári, University of Debrecen, Hungary

[OP] The influence of polymeric binder type and concentration on flow and dissolution properties of Syloid® 244FP-based SMEDDS granules
Mila Kovačević, University of Ljubljana, Slovenia

[OP] Pulmonary dry powder for inhalation for targeted drug delivery to macrophages in tuberculosis
Mahwash Mukhtar, University of Szeged, Hungary

[KL] Design, synthesis and biochemical evaluation of lowmolecular-weight human neutrophil elastase inhibitors
Aleš Obreza, University of Ljubljana, Slovenia

[OP] Fluorescent probes for detection of misfolded proteins, in biological samples
Damijan Knez, University of Ljubljana, Slovenia

[OP] Targeting cathepsin X in neurodegenerative diseases with novel triazole-benzodioxine inhibitors
Urša Pečar Fonović, University of Ljubljana, Slovenia

[OP] Chalcogen carbamates as covalent cholinesterase inhibitors – surveying group 16 (VI) of the periodic table
Anže Meden, University of Ljubljana, Slovenia

[OP] In vivo efficiency of a new liposomal adjuvant system based on porins
Selin Parmaksız, Hacettepe University, Turkey

Luncheons

[PL] 30 years in formulation of protein pharmaceuticals: What has been achieved- where do we stand today- what is next?
Gerhard Winter, Ludwig Maximilian University of Munich, Germany

Section: FORMULATION AND DELIVERY CHALLENGES OF SMALL MOLECULES AND BIOTECH DRUGS

Section: NEW MOLECULES FOR TREATING BACTERIAL AND VIRAL INFECTIONS

[KL] Electrospun antimicrobial peptides – novel approach for improved wound infection treatment
Kairi Lorenz, University of Tartu, Estonia

[KL] Semisynthetic glycopeptide antibiotics – one weapon against two deadly enemies
Anikó Borbás, University of Debrecen, Hungary

[KL] Bioinspired anisotropic magnetic nanoparticles: design, synthesis and biomedical applications
Slavko Kralj, J. Stefan Institute, Slovenia

[KL] Rational design of balanced dual-targeting antibacterial compounds with limited resistance
Lucija Peterlin Mašič, University of Ljubljana, Slovenia

Coffee break & Poster session

[KL] Real-time label-free sensing platforms for nanoparticle and extracellular vesicle analysis
Tapani Viitala, University of Helsinki & Åbo Akedemi University, Finland

[KL] Potent DNA gyrase inhibitors bind to their target through symmetrical bifurcated halogen bonding.
Marko Anderluh, University of Ljubljana, Slovenia

The viscosity reduction platform enabling subcutaneous delivery (Promotion lecture)
Peter Balogh, Merck

[OP] In vivo evaluation of doxorubicin and elacridar co-loaded PLGA/silica hybrid nanoparticles against multidrug resistant breast cancer
Hayrettin Tonbul, Inonu University, Turkey

[OP] Nanofibers for local delivery of two bacillus strains with antibacterial activity
Nina K. Grilc, University of Ljubljana, Slovenia

[OP] Development of cyclosporine A – loaded micelles exibiting a promising antiviral activity against SARS-CoV-2
Fabiola Guareschi, University of Parma, Italy

[OP] HDAC6 inhibition in cystic fibrosis: in vivo proof-ofconcept study anti-inflammatory profile, effects on bacterial load, formulation and biodistribution studies
Margherita Brindisi, University of Naples Federico II, Italy

[OP] New covalent reversible inhibitors of SARS-CoV-2 main protease
Sveva Pelliccia, University of Naples Federico II, Italy

[OP] Synthesis and biological evaluation of quinoline and anthranilic acid derivatives as potential quorum sensing inhibitors
Ivana Perković, University of Zagreb, Croatia

[OP] Expanding the chemical space of n-phenylpyrrolamides as DNA gyrase B inhibitors
Peter Peršolja, University of Ljubljana, Slovenia

Welcome reception

[PL] Mechanistic Understanding of Long-term Performance of Oral Medicines
Daniel Markl, University of Strathclyde, United Kingdom

[PL] Adoption of 3D printing technologies in pharmacies and hospital pharmacies
Niklas Sandler, Nanoform, Finland (on-line presentation)

Section: NEW TRENDS IN INDUSTRIAL PHARMACY

Section: EMERGING CONTAMINANTS IN EVNIRONMENTAL SAMPLES AND PHARMACEUTICAL PRODUCTS

[KL] Long-acting drug delivery to female health via polymeric intravaginal ring: Innovative and rational principles underlying formulation design and hot-melt extrusion processing
Amrit Paudel, Graz University of Technology, Austria

[KL] Mass spectrometry as a powerful tool for analysing degradation pathways: 1,4-benzodiazepine case study
Žiga Hodnik, Krka, d,d,, Slovenia

Coffee break & Poster session

[KL] Application of hot-melt technologies in designing formulations with poorly water-soluble active ingredient
Gregor Lorbek, Krka, d.d., Slovenia

[KL] Pharmaceutical residues in the aquatic environment Challenges and opportunities of using advanced analytical methods for their monitoring
Mira Petrović, ICRA Catalan Institute for Water Research, Spain

[OP] Rational development and process optimization of an amorphous solid dispersion generic drug product prepared by hot-melt extrusion (a case study)
Ognen Jakasanovski, Lek.d.d., Slovenia

[OP] Use of additives to control the polymorphism of solid lipid formulations: a simple way to face a complex problem
Serena Bertoni, University of Bologna, Italy

[OP] Fabrication of 3DP colon-targeted tablets including fluticasone with enhanced solubility by γ-cyclodextrin
Diren Sarısaltık Yaşın, Dicle University, Turkey

[OP] A useful method for routine monitoring of endocrine disruptors in surface waters by SPE-LC-MS/MS
Andrej Grobin, University of Ljubljana, Slovenia

[OP] Study of different sources of nitrosamine traces in pharmaceuticals by highly sensitive hyphenated mass spectrometry techniques
Nejc Golob, Lek d.d., Slovenia

[OP] Selective determination of whey proteins by a chromatographic analytical approach
Nika Osel, University of Ljubljana, Slovenia

Luncheons

[PL] Personalised medicine in Estonia – moving from research to practice
Sulev Reisberg. University of Tartu, Estonia

Section: CREATING USER FRIENDLY ORAL DOSAGE FORMS

Section: THERAPEUTIC DRUG MONITORING & PHARMACOGENOMICS AS A TOOL TO IMPROVE DRUG EFFICIENCY AND SAFETY IN PERSONALISED MEDICINE

[KL] Personalized medicine: Drug development and usage
Cansel Köse Özkan, University of Health Sciences, Turkey

[KL] Therapy personalization of anti-TNF drugs in pediatric patients with immune mediated diseases
Gabriele Stocco, University of Trieste, Italy

[KL] Microparticles and multi-unit systems for advanced drug delivery
István Antal, Semmelweis University, Hungary

[KL] Pharmacogenomic and biological implications of thiopurine S-methyltransferase
Dunja Urbančič, University of Ljubljana, Slovenia

Coffee break & Poster session

[OP] Preparation of buccal films in Parkinson’s disease
Krisztián Pamlényi, University of Szeged, Hungary

[OP] Design and evaluation of composite film formulations using quality by design for paediatric use
Genada Sinani, Altinbas University, Turkey

[OP] Development of a pediatric orally disintegrating tablet dosage form by masking the bitter taste of ornidazol with eudragit E PO
Gülbeyaz Yıldız Türkyılmaz, Ege University, Turkey

[OP] Nanocellulose-based orodispersible films as a potential drug delivery system
Katarina Bolko Seljak, University of Ljubljana, Slovenia

[OP] Excipients role in formulating user friendly oral dosage forms
Pawel Balcerzak, Lubrizol Advanced Materials, Inc., USA

[OP] A chitosan based bioadhesive gel for delivery of combined antimicrobials with enhanced activity in local treatment of skin infections in humans and animals
Ece Türkmen, Hacettepe University, Turkey

[KL] PK-PD modelling to optimise therapy and facilitate therapeutic drug monitoring of antimicrobials in neonates
Dr. Eva Germovšek, Boehringer Ingelheim, Germany

[KL] Model-informed precision dosing of ustekinumab in Crohn’s disease
Jurij Aguiar Zdovc, University of Ljubljana, Slovenia

[KL] Crossing ocular barriers: pharmacokinetic models to support drug development in retinal diseases
Eva del Amo Páez, University of Eastern Finland, Finland

[OP] Transcriptome analysis reveals involvement of thiopurine s-methyltransferase in oxidation-reduction processes
Alenka Šmid, University of Ljubljana, Slovenia

Congress Dinner

[PL] Microfluidics manufacturing of nanoparticle based formulations for pharmaceutical and biomedical applications
Helder Santos, University of Groningen, The Netherlands

Section: CONTEMPORARY CHALLENGES IN PHARMACEUTICS

Section: PEPTIDES AS THERAPEUTICS AND BIORECOGNITION ELEMENTS, M-RNA VACCINES

[KL] Physiologically based finite time pharmacokinetic (PBFTPK) models: the end of the beginning in oral drug absorption
Panos Macheras, National and Kapodistrian University of Athens, Greece

[KL] Peptides-based drug delivery systems for RNA therapeutics
Taavi Lehto, University of Tartu, Estonia

[OP] Microdialysis and nanofiltration allow to distinguish molecularly dissolved from colloid-associated drug concentrations during biomimetic dissolution testing of supersaturating formulations
Martin Brandl, University of Southern Denmark, Denmark

[OP] Memantine loaded PLGA nanoparticles for Alzheimer’s disease
Gizem Tezel, Hacettepe University & Süleyman Demirel University, Turkey

[KL] Short peptides and their role in research and immunotherapy of allergies
Mojca Lunder, University of Ljubljana, Slovenia

[OP] An assessments of titanate nanotubes performance as protein carriers
Tamás Sovány, University of Szeged, Hungary

[OP] Immunomodulatory properties of simvastatin embedded in liposomes and electrospun nanofibers for wound healing
Anže Zidar, University of Ljubljana, Slovenia

[KL] CD81 large extracellular loop as a novel alternative scaffold: laminin binding CD81 enhances specific uptake of extracellular vesicles
Gordana Wozniak Knopp, University of Natural Resources and Life Sciences, Austria

Coffee break & Poster session

[OP] The effect of the structure – the evaluation of the disintegration and the dissolution processes of 3D printed orodispersible tablets
Jolanta Pyteraf, Jagiellonian University Medical College, Poland

[OP] Exploring the potential of new bulking agents for lyophilised biopharmaceutical formulations intended for subcutaneous administration
Maja Bjelošević, University of Ljubljana, Slovenia

[OP] Cyclodextrin polymer-based siRNA delivery systems
Ágnes Rusznyák, University of Debrecen, Hungary

[OP] Open liquid-surface ultrasound-enhanced electrospinning for generating multilayered nanofiber structures
Arle Kõrkjas, University of Tartu, Estonia

Process related impurities in mRNA manufacturing (Promotion lecture)
Aleš Štrancar, BIA Separations

[OP] Development of peptides as affinity ligands for human antibody purification
Tomaž Bratkovič, University of Ljubljana, Slovenia

[OP] Expression, purification, and NMR investigation of human KHSRP DNA binding protein using E. coli system
Pasquale Russomanno, University of Naples Federico II, Italy

[OP] engineering IL-6-binding lactic acid bacteria for alleviation of inflammatory bowel disease
Abida Zahirović, Jožef Stefan Institute, Slovenia

Workshops for Young Scientists
(at University of Ljubljana, Faculty of Pharmacy)
https://www.sfd.si/9-konferenca-bbbb/programme/workshops-for-young-scientists/

Closing remarks